백서의 두개골 결손부에서 탈단백우골 이식 시 흡수성막의 효과
The effect of resorbable menbrane on bone regeneration in calvarial defects of rats
박영준, 박홍주, 국민석, 오희균, 유선열, 유민기, 최근호, 장정록, 정승곤, 김영준,
소속 상세정보
박영준 ( Park Young-Jun ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
박홍주 ( Park Hong-Ju ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
국민석 ( Kook Min-Suk ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
오희균 ( Oh Hee-Kyun ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
유선열 ( Ryu Sun-Youl ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
유민기 ( Yu Min-Gi ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
최근호 ( Choi Guen-Ho ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
장정록 ( Jang Jung-Rok ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
정승곤 ( Jung Seung-Gon ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
김영준 ( Kim Young-Joon ) - 전남대학교 치의학전문대학원 구강악안면외과학교실
KMID : 0360120090310050365
Abstract
Purpose: This research evaluates the effect of the use of absorbable membrane barrier with deproteinized bovine bone (Bio-, Switzerland) on bone healing in surgically created critical-sized defects in rat calvaria.
Materials and Methods : Two standardized transosseous circular calvarial defects (5 mm in diameter) are made in each calvarium of 30 rats. These rats are divided into negative control group(n=15), positive control group(n=15) and two experimental groups(n=15). In the negative control group, defects are only filled with blood clots. In the positive control group, defects are filled with autogenous bone obtained from calvarium; in the experimental group 1, defects are filled with deproteinized bovine bone; and in the experimental group 2, defects are filled with deproteinized bovine bone with absorbable membrane. At the postoperative 1 week, 3 weeks. and 6 weeks, clinical. histologic and histomorphometric evaluations of the defects are performed.
Results: 1. The grafted bone without membrane in the calvarial bone defect was scattered but, the grafted bone with membrane was stable. 2. membrane was absorbed beginning at 3 weeks, and was absorbed considerably at 6 weeks while maintaining the structural form of the membrane. 3. The use of membrane blocked soft tissue invasion. 4. In histomorphometric analysis. it showed the greatest amount of new bone formation in the positive control group. The amount of new bone formation was greater in the experimental group 2 than experimental group 1. At 6 weeks. the amount of new bone formation was greater in the positive control group than experimental group l(p<0.005).
Conclusion: These results suggest that membrane increase the stability of grafted bone and protects from soft tissue invasion, and the use of the membrane may promote new bone formation in deproteinized bovine bone graft area.
키워드
Deproteinized bovine bone;Bioabsorbable membrane;Bone regeneration
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